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新疆维吾尔族2型糖尿病患者Fosl2蛋白表达及与胰岛素抵抗及胰岛β细胞功能的关系

来自:金沙赌玚下载  编辑:候俊霞 阳毅 李思源等|点击数:|2016-03-06

 

    【摘要】  目的  探讨新疆维吾尔族T2DM患者Fosl2蛋白表达,及与IR和胰岛β细胞功能的关系。  方法   收集新疆喀什地区维吾尔族T2DM患者(T2DM组)及非糖尿病者(Non-DM组),各50例,测量身高、体重、WC、臀围、SBP、DBP,检测FPG、HbA1c、FIns、血脂及Fosl2蛋白水平,计算BMI、WHR、胰岛素抵抗指数(HOMA-IR)、胰岛β细胞功能指数(HOMA-β)及胰岛素敏感指数(HOMA-IS)。  结果 (1)T2DM组Fosl2蛋白水平[(18.09±19.48)vs(41.48±26.32) ng/ml]、HOMA-IS[(-4.93±

0.73)vs(-3.90±0.80)]及HOMA-β[(3.63±0.97)vs(4.65±0.85)]低于Non-DM组(P<0.01),而BMI、FPG、HbA1c、TC、TG、LDL-C、HDL-C、FIns及HOMA-IR均高于Non-DM组(P<0.05);(2)相关性分析显示,在维吾尔族人群中,Fosl2水平与BMI、FPG、HbA1c、TC、HOMA-IR呈负相关(P<0.05),与HOMA-IS呈正相关(P<0.01);在维吾尔族T2DM组中,Fosl2水平与TG呈正相关,与FIns、HOMA-β呈负相关(r=0.536、-0.465、-0.469,P<0.05)。  结论  Fosl2蛋白表达水平与新疆维吾尔族IR、胰岛β细胞功能密切相关,Fosl2蛋白表达水平下调可能参与了维吾尔族T2DM的发生发展。

   【关键词】  新疆维吾尔族;Fosl2基因;糖尿病,2型;胰岛素抵抗;胰岛β细胞功能。

   The relationship between Fosl2 protein expression and insulin resistance and β-cell function in type 2 diabetes in Xinjiang Uygurs 

   【Abstract  Objective   To detect the relationship between Fosl2 protein expression and insulin resistance and β-cell function in patient with type 2 diabetesT2DM in Xinjiang Uygurs.  Methods   50 cases with T2DM (T2DM group) and 50 non-diabetic controls (Non-DM group) were recruited in Uygurs. All the subjects accepted physical examinations including height, weight, waist circumference, hip circumferenceSBP, and DBP. The levels of FPG, HbA1c, FIns, and lipids and the expression of Fosl2 protein were detected. The indicators of BMI, WHR, Insulin resistance index (HOMA-IR), insulin-β cell function index (HOMA-β) and insulin sensitivity index (HOMA-IS) were calculated.  Results  1The expression of Fosl2 protein in T2DM group (41.48 ± 26.32) ng/mL was significantly lower than in Non-DM group (41.48 ± 26.32ng/mL. Compared with Non-T2DM group, lnHOMA-IS and lnHOMA-β were significantly lower in T2DM group in Xinjiang Uygurs(P0.01, while BMI, FPG, HbA1c, TC, TG, LDL-C, HDL-C, FIns and HOMA-IR levels were higherP0.01. 2Pearson correla-tion analysis showed that the expression of Fosl2 protein negatively correlated with BMI, FPG, HbA1c,TC and HOMA-IR(P0.05), and positively correlated with HOMA-IS in Uygur(P0.01). The expression of Fosl2 protein had positive correlation with TG, and negative correlation with FIns, HOMA-βr=-0.465-0.469P0.05) in T2DM group in Xinjiang Uygurs.  Conclusion  The expression of Fosl2 protein was related with insulin resistance and β-cell function of Uygurs. The down regulation of Fosl2 protein expression may involved in the development of T2DM in Xinjiang Uygurs.

Key words Xinjiang Uygur; Fosl2 gene ;Type 2 Diabetes ;insulin resistance; pancreatic β-cell function

 

上一篇:2型糖尿病合并抑郁患者炎性因子和胰岛素抵抗指数的变化及其临床意义 下一篇:2型糖尿病患者合并低T3综合征与糖化血红蛋白和胰岛β细胞功能相关性的研究

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